A Prospective Open‐label Trial Of A CBD/THC Cannabis Oil In Dravet Syndrome

Cannabis Oil and Epylepsy

Twenty kids with a rare form of epilepsy have exhibited positive responses as the frequency of their seizures drastically dropped after being exposed to cannabis oil.

The research was commissioned by The Little Rocky Project and Tilray and titled, “A prospective open‐label trial of a CBD/THC cannabis oil in dravet syndrome.” Dravet Syndrome is a genetic disorder that is often misdiagnosed. It’s said to affect 1 in 20,000-40,000 kids.

Although CBD is an active ingredient of marijuana, it’s distinct from weed due to the absence of THC or delta-9 tetrahydrocannabinol. This is the psychoactive ingredient that creates the high for users. However, CBD remains listed as a Schedule I controlled substance. Patients cannot freely purchase CBD except in states where medical marijuana has been legalized.

Where is Marijuana Legal?

To date, there are 31 states in the US, along with the District of Colombia, that allows the use of marijuana for medical purposes. There are also nine states that allow for the use of recreational marijuana. These include Colorado, Alaska, California, Maine, Massachusetts, Nevada, Oregon, Vermont, Washington State, and Washington DC.

For the study, a controlled sample of 20 kids suffering from Dravet were given an experimental product dubbed TIL-TC150 at The Hospital for Sick Children. The ratio of (cannabinoid) CBD and THC for the oil was 50:1.

Testing the Product

Some of the kids have been suffering from more than 1,000 seizures per month. This contributes to delays in their development and learning, while significantly reducing their quality of life. Unfortunately for those with this condition, there’s no known cure.

One of the participants in the research study, 16-year-old Abigail, started off with an average of eight to ten seizures every month to “less than one every two months” after taking cannabis oil, recounted her mother. As the seizures went down, her development also improved. You can read more about it in this article.

The Result

The result of this research is not uncommon. In fact, there are plenty of studies that established the positive response of epilepsy patients to cannabis oil. The US Federal Drugs Administration announced in June 2018 that it approved Epidiolex (cannabidiol) oral solution to specifically control the seizures for patients 2 years and older. It was the first time that the agency approved a cannabis-based medicine for epilepsy. The clinical trials revealed that the frequency of seizures for participating patients declined by an average of 54%.

However, Dr. Orrin Devinsky, NYU Comprehensive Epilepsy Center director, reported that the kids who took cannabis oil also suffered from side effects such as vomiting, fever, and fatigue, and that these reactions range from mild to moderate. The benefits, however, far outweigh the disadvantages as the children have reclaimed their lives after the frequency of their debilitating seizures were drastically reduced. In addition, the negative side effects began to decrease as they developed more tolerance to the CBD.

Meanwhile, more ongoing research studies are being conducted to determine other medical uses of cannabis oil. Cannabis oil has been known to slow down the onset of Alzheimer’s, relieve pain, regulate appetite, encourage sleep, stabilize tremors, and treat post-traumatic stress syndrome.

Doses & Search

The proper dose for anyone is not a consistent science, not everyone will get the same effects from the same dose of CBD to THC. Finding the optimal dose for yourself could be a slight trial and error. If you’re not used to the psychoactive effects of the THC, focus on higher ratios of CBD before you step into a 1:1 ratio. Maybe start with 3:1 and increase your CBD from that starting point. The best decision is to consult directly with your general physician before following anything you read online.

Most of the CBD items sold through an average dispensary (over the counter) will be a good start but the CBD to THC ratio of 50:1 as mentioned in this research may be tough to come by. This ratio of product is not always easily accessible and especially in states where strict cannabis regulations have been put in place.

You can find natural CBD products through a local medical or recreational dispensary or as recommended, consult first with your favorite physician. To find a dispensary in your area and begin the search for high quality CBD oils, visit Cannabexchange dispensary directory listing.


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